INVESTIGATION OF DISSOLUTION MECHANISM AND RELEASE KINETICS OF POORLY WATER-SOLUBLE TADALAFIL FROM AMORPHOUS SOLID DISPERSIONS PREPARED BY VARIOUS METHODS

Investigation of Dissolution Mechanism and Release Kinetics of Poorly Water-Soluble Tadalafil from Amorphous Solid Dispersions Prepared by Various Methods

The aims of this study were to investigate how the release of tadalafil is influenced by two grades of polyvinylpyrrolidone (Kollidon® 12 PF and Kollidon® VA 64) and various methods of preparing solid dispersions (solvent evaporation, spray drying and hot-melt extrusion).Tadalafil is poorly water-soluble and its high melting point makes i

read more

A ribodepletion and tagging protocol to multiplex samples for RNA-seq based virus detection: application to the cassava virome

Abstract Background Cassava (Manihot esculenta, Crantz), is a staple food and the main source of calories for many populations in Africa, but the plant is beset by several damaging viruses.So far, eight families of color touch 7/97 virus infecting cassava have been identified; the Geminiviridae (ssDNA viruses responsible for cassava mosaic disease,

read more


Studying of New Bio-Fertilizer Formula Composed of Streptomyces and Nitrogen Fixing Bacteria to Sustain Vigna Radiate (L.)

The recent study aimed to develop and produce bio-fertilizer as a supplement to chemical fertilizers, with the goal to reduce their application.In this study, new Streptomyces species were introduced along with nitrogen-fixing bacteria to support the growth of Mung beans in Iraq.The experiment involved the application of five strains of Rhizobium,

read more